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Acute Myelogenous Leukemia: Genetics, Biology and Therapy by Zeev Estrov (auth.), Lalitha Nagarajan (eds.)

By Zeev Estrov (auth.), Lalitha Nagarajan (eds.)

Acute myelogenous leukemia (AML), is the commonest type of leukemia in adults. AML is a perilous type of malignancy, the diagnosis for which has no longer superior within the final twenty years. extra importantly, it's a malignancy that's obvious in older adults, consequently the variety of instances is probably going to upward thrust because the inhabitants a long time.

Over the previous 15 years, genetic mechanisms underlying AML have all started to spread. extra learn during this quarter has helped determine key elements and features. for that reason, detailed remedy of AML is receiving a lot cognizance. it's the wish of researchers that as with continual myelogenous leukemia (CML), and the drug, Gleevec, a certain remedy for AML may be discovered.

"The powerful therapy of acute myelogenous leukemia continues to be a superb problem. this article reports our realizing of the molecular and biologic foundation of the ailment. prime investigators deal with advances in prognostication and healing thoughts that experience major promise."

Steven T. Rosen, M.D.
Series Editor

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Acute Myelogenous Leukemia: Genetics, Biology and Therapy

Acute myelogenous leukemia (AML), is the commonest kind of leukemia in adults. AML is a dangerous kind of malignancy, the diagnosis for which has no longer more suitable within the final 20 years. extra importantly, it's a malignancy that's obvious in older adults, consequently the variety of instances is probably going to upward thrust because the inhabitants a while.

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Extra resources for Acute Myelogenous Leukemia: Genetics, Biology and Therapy

Sample text

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1982;257(4):2041–2048. 36. Cross SH, Meehan RR, Nan X, Bird A. A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nat Genet. 1997;16(3):256–259. 37. Daskalakis M, Nguyen TT, Nguyen C, et al. Demethylation of a hypermethylated P15/ INK4B gene in patients with myelodysplastic syndrome by 5-Aza-20 -deoxycytidine (decitabine) treatment. Blood. 2002;100(8):2957–2964. 38. De Marzo AM, Marchi VL, Yang ES, Veeraswamy R, Lin X, Nelson WG. Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.

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